|
| Status |
Public on Jun 04, 2024 |
| Title |
Tumor cell intrinsic type I interferon signaling dictates CD47-SIRPα blockade immunotherapy via metabolic reprograming [dataset 1] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Innate immune checkpoint has emerging as a highly potential target for cancer immunotherapy in recent years. The CD47-SIRPα axis is the best-studied innate checkpoint in cancer. However, the transcription profile of tumor cell duiring CD47-SIRPα blockade therapy remains unclear.
|
| |
|
| Overall design |
C57BL/6 mice (n=3 per group) transplanted s.c. with 5×10E5 MC38 cells were treated i.t. with 50 μg CV-1 or hIgG every three days. Two days after the third treatment, CD45- cells were sorted for the generation of RNA-seq libraries.
|
| |
|
| Contributor(s) |
Zhou H, Wang W, Ding J, Zhu M |
| Citation(s) |
38982116 |
| |
| Submission date |
Jun 16, 2023 |
| Last update date |
Aug 08, 2024 |
| Contact name |
Mingzhao Zhu |
| E-mail(s) |
zhumz@ibp.ac.cn
|
| Phone |
8610-64888775
|
| Organization name |
Institute of Biophysics, Chinese Academy of Sciences
|
| Department |
Key Laboratory of Infection and Immunity
|
| Street address |
15 Da Tun Rd, Chaoyang District
|
| City |
Beijing |
| ZIP/Postal code |
100101 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (5)
|
|
| This SubSeries is part of SuperSeries: |
| GSE235113 |
Tumor cell intrinsic type I interferon signaling dictates CD47-SIRPα blockade immunotherapy via metabolic reprograming. |
|
| Relations |
| BioProject |
PRJNA984610 |
Less...
More...