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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 27, 2023 |
| Title |
An mRNA-based universal vaccine candidate confers improved cross-protection against heterosubtypic influenza viruses in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The single-cell transcriptional profiling of T cells in the spleens of vaccinated mice revealed that the mRNA-based vaccine significantly promoted CD8+ T cells and memory T cells by prime-boost immunization.
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| Overall design |
The single-cell transcriptional profiling of cells in spleens 7 days post-prime and boost immunization was performed to gain further insights into the cellular and molecular mechanisms involved in the mRNA-based universal vaccine.
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| Contributor(s) |
Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y, Luo J, Li X |
| Citation(s) |
37671994 |
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| Submission date |
Jun 12, 2023 |
| Last update date |
Sep 28, 2023 |
| Contact name |
Feifei Xiong |
| E-mail(s) |
xiongfeifei@sinopharm.com
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| Organization name |
Shanghai Institute of Biological Products
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| Street address |
350 Anshun Rd，Shanghai
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| City |
Shanghai |
| ZIP/Postal code |
200052 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
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| GSM7474278 |
Prime2, replicate 2, scRNAseq |
| GSM7474279 |
Prime3, replicate 3, scRNAseq |
| GSM7474280 |
Prime_Boost1, replicate 1, scRNAseq |
| GSM7474281 |
Prime_Boost2, replicate 2, scRNAseq |
| GSM7474282 |
Prime_Boost3, replicate 3, scRNAseq |
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| Relations |
| BioProject |
PRJNA982857 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE234756_RAW.tar |
372.8 Mb |
(http)(custom) |
TAR (of TAR) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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