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| Status |
Public on Jun 17, 2023 |
| Title |
Dissecting the mechanisms underlying the Cytokine Release Syndrome (CRS) mediated by T Cell Bispecific Antibodies |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed bulk RNAseq of HUVECs exposed to cytokine-rich supernatant from T cell dependent cytotoxicity assay with CEA-TCB or DP47-TCB (untargeted-TCB; negative control) to study their activation and contribution to cytokine release.
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| Overall design |
Supernatants from T cell dependent cytotoxicity assay with DP47-TCB (untargeted-TCB) or CEA-TCB were collected and transferred to HUVECs for 6 hrs. At assay endpoints (6hrs), HUVECs were collected, washed and lysed for bulk RNAseq.
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| Contributor(s) |
Leclercq-Cohen G, Danilin S, Bianchi R, Biehl M, Alberti-Servera L, Nassiri S, Bacac M |
| Citation(s) |
37379429 |
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| Submission date |
Jun 12, 2023 |
| Last update date |
Sep 18, 2023 |
| Contact name |
Marina Bacac |
| Organization name |
Roche Glycart AG
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| Department |
Oncology Discovery
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| Street address |
Wagistrasse 10
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| City |
Schlieren |
| ZIP/Postal code |
8952 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE234676 |
Dissecting the mechanisms underlying the Cytokine Release Syndrome (CRS) mediated by T Cell Bispecific Antibodies |
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| Relations |
| BioProject |
PRJNA982733 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE234668_raw_count.csv.gz |
324.3 Kb |
(ftp)(http) |
CSV |
| GSE234668_raw_tpm.csv.gz |
689.1 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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