A cocktail of five bioinformatically and experimentally prioritized recombinant proteins was used immunize pigs and test for active antibody responses.
Overall design
This antibody-protein array of putative immunogenic proteins was developed using bioinformatic, experimental, and literature-based parasite protein targets. Screening the array with sera and ileal fluid samples from immunized pigs suggested cross-reactivity among homologous proteins and general immunity activation. Overall immune responses were significantly altered by immunization, but not by direct worm challenge.
Rosa BA, Zarlenga DS, Fournet VM, Beshah E, Hill DE, Zarlenga A, Yee A, Liang X, Shandling AD, Oberai A, Urban JF Jr and Mitreva M. Identification of broadly-conserved parasitic nematode proteins that activate immunity. Front. Parasitol. 2003; 2:1223942. doi:10.3389/fpara.2023.1223942
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