|
| Status |
Public on May 08, 2024 |
| Title |
Transcriptomics profiling of lymphocytes from patients with resolved or chronic HBV infection |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We generated transcriptional profiles of CD4 T cells, CD8 T cells, as well as a subset of CD 8 T cells that are specific for human hepatistis B virus core protein (HBcore or HBV_core) with bulk RNA sequencing. CD4 T cells are further stratified by PD1 expression profile (low or high).
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| |
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| Overall design |
CD4, CD8, and HBcore-specific T cells were isolated from blood of non-HBV patients (HV), patients with chronic HBV infection (cHBV), and patients with resolved HBV infection (rHBV).
|
| Web link |
https://www.nature.com/articles/s41586-024-07630-7
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| |
|
| Contributor(s) |
Kumpesa N, Siebourg-Polster J, Zhang JD, Heim K, Thimme R |
| Citation(s) |
38987588 |
| |
| Submission date |
May 29, 2023 |
| Last update date |
Aug 07, 2024 |
| Contact name |
Jitao David Zhang |
| E-mail(s) |
jitao_david.zhang@roche.com
|
| Phone |
+41616886251
|
| Organization name |
F. Hoffmann-La Roche
|
| Department |
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel
|
| Lab |
Pharmaceutical Sciences
|
| Street address |
Grenzacherstrasse 124
|
| City |
Basel |
| ZIP/Postal code |
4070 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (71)
|
|
| Relations |
| BioProject |
PRJNA977249 |
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