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Series GSE23338 Query DataSets for GSE23338
Status Public on May 31, 2011
Title TGFß1-driven epithelial to mesenchymal transition in human kidney cell line
Organism Homo sapiens
Experiment type Expression profiling by array
Summary TGFbeta is the major cytokine driver of fibrosis in the kidney and other tissue. Epithelial-mesenchymal transition has been postulated to contibrute to renal fibrosis in diseases such as diabetic nephropathy.
We wished to identify novel genes that were upregulated in human kidney epithelial cells in response to TGFb1.The transcriptional responses for human proximal tubule epithelial cells to 10 ng/ml TGFbeta1 was examined over 24 and 48 hr
Overall design There were three treatment groups: vehicle, 24hr TGFb1, 48 hr TGFb1. Each treatment was carried out in triplicate 10 cm plates and the experiment was carried out in triplicate using consecutive passages of cells.
Contributor(s) Brazil DP, Roxburgh SA
Citation(s) 22266139
Submission date Jul 30, 2010
Last update date Dec 06, 2018
Contact name Derek P Brazil
Organization name Queen's University
Street address Grosvenor Road
City Belfast
ZIP/Postal code BT12 6BA
Country United Kingdom
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (9)
GSM572738 HK-2 cells, 0hrs_rep1
GSM572739 HK-2 cells, 24hrs_rep1
GSM572740 HK-2 cells, 48hrs_rep1
BioProject PRJNA131473

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Supplementary file Size Download File type/resource
GSE23338_RAW.tar 15.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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