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| Status |
Public on Sep 12, 2024 |
| Title |
Single-nucleus RNA-Seq and spatial transcriptomics characterization of Alzheimer’s Disease and Down Syndrome |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
The highly dynamic regulatory networks involved in brain processes can result in specific gene expression patterns across distinct cell types. The single-nucleus and spatial transcriptomics data allow us to better understand these patterns. This study involved the analyses of the brains of mice and humans with Alzheimer’s Disease (AD) and Down Syndrome.
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| Overall design |
Spatial and single nuclei transcriptomics analysis of Alzheimer's Disease and Down Syndrome in human and mouse brain tissue using single-nucleus RNA-seq and visium platform.
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| |
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| Contributor(s) |
Samuel M, Emily M, Vivek S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 23, 2023 |
| Last update date |
Sep 12, 2024 |
| Contact name |
Negin Rahimzadeh |
| E-mail(s) |
nrahimza@uci.edu
|
| Organization name |
UCI
|
| Street address |
3224 Biological Sciences III
|
| City |
Irvine |
| State/province |
CA |
| ZIP/Postal code |
92697 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (185)
|
|
| Relations |
| BioProject |
PRJNA975472 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE233208_5XFAD_8samples.csv.gz |
559 b |
(ftp)(http) |
CSV |
| GSE233208_5XFAD_seurat_processed_annotated.rds.gz |
3.9 Gb |
(ftp)(http) |
RDS |
| GSE233208_AD-DS_Cases.csv.gz |
2.0 Kb |
(ftp)(http) |
CSV |
| GSE233208_Human_snRNA-Seq_ADDS_integrated.rds.gz |
3.3 Gb |
(ftp)(http) |
RDS |
| GSE233208_Human_visium_ADDS_seurat_processed.rds.gz |
1.4 Gb |
(ftp)(http) |
RDS |
| GSE233208_pilot_samples.csv.gz |
110 b |
(ftp)(http) |
CSV |
| GSE233208_visium_5xFAD_11-15-21_sample_meta.csv.gz |
790 b |
(ftp)(http) |
CSV |
| GSE233208_visium_5xFAD_11-24-21_sample_meta.csv.gz |
803 b |
(ftp)(http) |
CSV |
| GSE233208_visium_5xFAD_12-13-21_sample_meta.csv.gz |
522 b |
(ftp)(http) |
CSV |
| GSE233208_visium_5xFAD_12-20-21_sample_meta.csv.gz |
1.1 Kb |
(ftp)(http) |
CSV |
| GSE233208_visium_human_11-24-21_sample_meta.csv.gz |
804 b |
(ftp)(http) |
CSV |
| GSE233208_visium_human_12-13-21_sample_meta.csv.gz |
535 b |
(ftp)(http) |
CSV |
| GSE233208_visium_human_12-20-21_sample_meta.csv.gz |
537 b |
(ftp)(http) |
CSV |
| GSE233208_visium_human_Oct_2021.csv.gz |
520 b |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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