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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 27, 2023 |
| Title |
Targeting aberrant sialylation and fucosylation in prostate cancer cells using potent metabolic inhibitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To identify signalling pathways altered by treating prostate cancer cells with the metabolic inhibitors P-SiaFNEtoc, Fucotrim I and Fucotrim II, we treated CWR22Rv1 cells with P-SiaFNEtoc, Fucotrim I and Fucotrim II for 72 hours and their respective vehicle control with DMSO.
We then performed differential gene expression, Gene Ontology and GSEA analyses using data obtained from RNA-seq of the control and treated cell lines.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for vehicle control CWR22Rv1 cells vs CWR22Rv1 cells treated with metabolic inhibitors.
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| Contributor(s) |
Orozco-Moreno M, Visser EA, Hodgson K, Hipgrave Ederveen AL, Bastian K, Archer Goode E, Özturk Ö, Pijnenborg JF, Eerden N, Moons SJ, Rossing E, Wang N, de Haan N, Büll C, Boltje TJ, Munkley J |
| Citation(s) |
37847613 |
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| Submission date |
May 16, 2023 |
| Last update date |
Jan 30, 2024 |
| Contact name |
Jennifer Munkley |
| Organization name |
Newcastle University
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| Street address |
International Centre for Life
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| City |
Newcastle upon Tyne |
| State/province |
Tyne & Wear |
| ZIP/Postal code |
NE1 3BZ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (14)
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| GSM7360075 |
CWR22Rv1 cells, DMSO Control, biol rep 1 |
| GSM7360076 |
CWR22Rv1 cells, DMSO Control, biol rep 2 |
| GSM7360077 |
CWR22Rv1 cells, DMSO Control, biol rep 3 |
| GSM7360078 |
CWR22Rv1 cells, P-SiaFNEtoc treated, biol rep 1 |
| GSM7360079 |
CWR22Rv1 cells, P-SiaFNEtoc treated, biol rep 2 |
| GSM7360080 |
CWR22Rv1 cells, P-SiaFNEtoc treated, biol rep 3 |
| GSM7360081 |
CWR22Rv1 cells, Fucotrim I treated, biol rep 1 |
| GSM7360082 |
CWR22Rv1 cells, Fucotrim I treated, biol rep 2 |
| GSM7360083 |
CWR22Rv1 cells, Fucotrim I treated, biol rep 3 |
| GSM7360084 |
CWR22Rv1 cells, Fucotrim II treated, biol rep 1 |
| GSM7360085 |
CWR22Rv1 cells, Fucotrim II treated, biol rep 2 |
| GSM7835074 |
CWR22Rv1 cells, 2FF treated, biol rep 1 |
| GSM7835075 |
CWR22Rv1 cells, 2FF treated, biol rep 2 |
| GSM7835076 |
CWR22Rv1 cells, 2FF treated, biol rep 3 |
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| Relations |
| BioProject |
PRJNA973036 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE232621_CWR_CTL-2FF_counts.tabular.txt.gz |
248.6 Kb |
(ftp)(http) |
TXT |
| GSE232621_CWR_CTL-FucotrimII_counts.tabular.txt.gz |
576.2 Kb |
(ftp)(http) |
TXT |
| GSE232621_CWR_CTL-FucotrimI_counts.tabular.txt.gz |
606.4 Kb |
(ftp)(http) |
TXT |
| GSE232621_CWR_CTL-P-SiaFNEtoc_counts.tabular.txt.gz |
610.0 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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