|
| Status |
Public on Jun 02, 2023 |
| Title |
ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To explore the molecular mechanisms how ARIH1 activates CD8+ T cells and enhances PD-L1 blockade therapy, we performed RNA sequencing (RNA-seq) to determine whether Arih1 overexpression affects the gene expression in 4T1 cells.
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| |
|
| Overall design |
GSEA analysis of the enrichment of top pathways (left) for genes between Arih1-WT-OE and Arih1-C355S-OE 4T1 cells.
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| |
|
| Contributor(s) |
Liu X, Xia H |
| Citation(s) |
37429863 |
| |
| Submission date |
May 04, 2023 |
| Last update date |
Sep 12, 2023 |
| Contact name |
liu xiaolan |
| E-mail(s) |
12018099@zju.edu.cn
|
| Phone |
13588746219
|
| Organization name |
Zhejiang University Medical Center
|
| Street address |
1369 West Wenyi Road, Hangzhou 311121, China
|
| City |
hangzhou |
| ZIP/Postal code |
311121 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA967357 |
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