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Series GSE23113 Query DataSets for GSE23113
Status Public on Dec 31, 2010
Title Transcriptome Signatures of Sezary Cells from Patients and Cultured Hut 78, Hut 102 and Jurkat Cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Comparative transcriptome profiles of patient-derived Sezary cells and cultured Sezary cell line (Hut78) mycosis fungoides cell line (Hut 102) and non-Sezary T cell leukemia cell line (Jurkat) relative to benign CD4+ T cells from individuals with no T cell malignancy. There are three goals. The first and primary goal is to establish a list of genes with differential expression between Sezary cells and the benign CD4+ T cell counter part from individuals without Sezary syndrome. A secondary goal is to examine if these differentially expresses genes in clinical samples of Sezary cells are preserved in Hut78 and Hut102 cells, which are the two most frequently used experimental cell models of Sezary cells in the research community. The third goal is to examine if these Sezary cell specific genes are also present in a non-Sezary T cell malignancy, such as Jurkat cells, which is derived from a non-Sezary cell T cell leukemia patient.
Overall design Two color experiment, 6 biological replicates (6 unique patients) with Sezary syndrome, 1 Hut78 cell,1 Hut102 cell and 1 Jurkat cell lines as the experimental samples, each compared with a distinct individual with no T cell malignancy of the skin or the blood.
Contributor(s) Su M, Zhou Y, Wang Y
Citation(s) 21270445
Submission date Jul 23, 2010
Last update date Feb 22, 2018
Contact name Youwen Zhou
Organization name University of British Columbia
Street address 835 W 10th Ave
City Vancouver
ZIP/Postal code V5Z 4E8
Country Canada
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (9)
GSM569434 Sezary cell replicate 1
GSM569435 Sezary cell replicate 2
GSM569436 Sezary cell replicate 3
BioProject PRJNA131499

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Supplementary file Size Download File type/resource
GSE23113_RAW.tar 119.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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