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| Status |
Public on Jul 24, 2010 |
| Title |
Profiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
|
| Summary |
Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the predicted target genes in leiomyomas and matched myometria.
We found that some but not all of the predicted and inversely correlated target genes in ULMs can be directly regulated by microRNAs in vitro. Our findings provide a broad overview of molecular events underlying the tumorigenesis of uterine leiomyoma and identify select genetic and regulatory events that alter microRNA expression and may play important roles in ULM pathobiology by positively regulating tumor growth while maintaining the non-invasive character of ULMs
Keywords: Differential gene expression
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| Overall design |
Paired normal (myometrium) and tumor (ULM) samples derived from 5 patients were used
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| Contributor(s) |
Zavadil J, Ye H, Liu Z, Wu J, Lee P, Hernando E, Soteropoulos P, Toruner GA, Wei J |
| Citation(s) |
20808773 |
| |
| Submission date |
Jul 23, 2010 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Jiri ZAVADIL |
| E-mail(s) |
zavadilj@iarc.fr
|
| Phone |
+33648065733
|
| Organization name |
IARC WHO
|
| Street address |
150 COURS ALBERT THOMAS
|
| City |
LYON |
| State/province |
Other |
| ZIP/Postal code |
69008 |
| Country |
France |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA131497 |
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