|
| Status |
Public on May 30, 2023 |
| Title |
Stress response by phase-separated p62 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the role of p62 phosphorylation by ULK1 on NRF2 activation in vivo.
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| |
|
| Overall design |
We then generated p62S351E/+ mice, phosphomimetic knock-in mice in which Ser351 corresponding to human Ser349 replaced by Glu. The livers from p62+/+ and p62S351E/+ mice at P19 were subjected to mRNA-seq analysis.
|
| Web link |
https://www.embopress.org/doi/full/10.15252/embj.2022113349
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| |
|
| Contributor(s) |
Komatsu M, Takada S, Morishita H, Koga T |
| Citation(s) |
37306101 |
| |
| Submission date |
Apr 14, 2023 |
| Last update date |
Aug 29, 2023 |
| Contact name |
Masaaki Komatsu |
| E-mail(s) |
mkomatsu@juntendo.ac.jp
|
| Phone |
81-3-5802-1029
|
| Organization name |
Juntendo University Graduate School of Medicine
|
| Department |
Department of Physiology
|
| Street address |
Hongo 2-1-1
|
| City |
Tokyo |
| ZIP/Postal code |
113-8421 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (6)
|
| GSM7173778 |
Mouse liver at P19 of wild-type mouse -1 |
| GSM7173779 |
Mouse liver at P19 of wild-type mouse -2 |
| GSM7173780 |
Mouse liver at P19 of wild-type mouse -3 |
| GSM7173781 |
Mouse liver at P19 of p62 S351E/+ mouse -1 |
| GSM7173782 |
Mouse liver at P19 of p62 S351E/+ mouse -2 |
| GSM7173783 |
Mouse liver at P19 of p62 S351E/+ mouse -3 |
|
| Relations |
| BioProject |
PRJNA955674 |
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