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| Status |
Public on Apr 03, 2024 |
| Title |
NOTCH3 promotes vascular smooth muscle cells progression by targeting RANBP1 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Vascular smooth muscle cells participate in the formation and development of fibrous cap in the early stage of atherosclerosis,Notch3 plays an important role in maintaining the phenotypic stability of VSMCs.However,the molecular mechanism between Notch3 and VSMCs is not fully understood
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| Overall design |
Comparative gene expression profiling analysis of RNA-sequencing data，9 groups of vascular smooth muscle cells Samples for RNA-Sequencing , 3 groups of si-NOTCH3-1, 3 groups of si-NOTCH3-2 and 3 groups of normal control (NC) data, in which NOTCH3 was knocked down by different siRNAs.
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| |
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| Contributor(s) |
Xu Z, Xu J, Wei T, Zeng C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 08, 2023 |
| Last update date |
Apr 03, 2024 |
| Contact name |
zhongjiao xu |
| E-mail(s) |
zhongjiaoxu52@126.com
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| Organization name |
The Fifth Affiliated Hospital of Wenzhou Medical University
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| Street address |
No. 289, Gucang Road, Liandu District
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| City |
Lishui City |
| ZIP/Postal code |
323000 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA953624 |
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