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| Status |
Public on Oct 16, 2023 |
| Title |
RNA-seq profiling of Drosophila larval ring glands of kdm5 null mutants |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
kdm5 is an essential gene in Drosophila that has critical developmental roles in the prothoracic gland cells of the larval ring gland. We performed a bulk transcriptome analysis of the larval ring gland in w[1118] (wild type) and kdm5[140] (null mutant) in order to identify genes in the prothoracic gland involved in the lethality of kdm5 null mutants. We found that the absence of kdm5 causes dysregulation of genes involved in various metabolic pathways. In particular, genes both bound by KDM5 and differentially expressed in this cell type are involved in regulation of mitochondrial biology and autophagy.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for Drosophila larval ring glands of wild type and kdm5 null animals
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| Contributor(s) |
Rogers MF, Marshall OJ, Secombe J |
| Citation(s) |
37800333 |
| |
| Submission date |
Apr 05, 2023 |
| Last update date |
Dec 06, 2023 |
| Contact name |
Michael Francis Rogers |
| E-mail(s) |
michael.rogers@einsteinmed.org
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| Organization name |
Albert Einstein College of Medicine
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| Department |
Genetics
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| Lab |
Julie Secombe, Ph.D.
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| Street address |
1300 Morris Park Ave, Ullmann 809
|
| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
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| Platforms (1) |
| GPL25244 |
Illumina NovaSeq 6000 (Drosophila melanogaster) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE229077 |
KDM5 binding and kdm5 null mutant differential expression profiling of Drosophila prothoracic gland cells |
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| Relations |
| BioProject |
PRJNA952685 |
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