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| Status |
Public on Oct 16, 2023 |
| Title |
MYC oncogene reprograms the local tissue microenvironment during prostate carcinogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the casual sequelae of MYC activation in the prostate tumor microenvironment (TME), we modeled MYC activation in the prostate TME using the transgenic Hi-Myc mouse model of prostate cancer.
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| Overall design |
We carried out scRNA-seq from each prostate lobe (anterior, dorsal, lateral, and ventral) of the MYC-driven mouse model of prostate cancer (Hi-MYC) in 6 month old mice in both FVB/NJ (N = 2) and C57BL/6J (N =2) mouse strains, as well as age-matched wild type animals (FVB/NJ N =2, C57BL/6J N = 3). Additionally we performed scRNA-seq analysis in the dorsal and lateral lobes of 10 month (+/- 6 weeks) old mice FVB/NJ Hi-Myc mice (N = 2) and age matched WT dorsal and lateral lobes (N = 2).
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| Contributor(s) |
Graham MK, Wang R, Yegnasubramanian S |
| Citation(s) |
39198404 |
| |
| Submission date |
Apr 04, 2023 |
| Last update date |
Sep 30, 2024 |
| Contact name |
Mindy Kim Graham |
| E-mail(s) |
mindy.graham@northwestern.edu
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| Phone |
4104046391
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| Organization name |
Northwestern University Feinberg School of Medicine
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| Department |
Urology
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| Street address |
303 E. Superior Street Chicago
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60611 |
| Country |
USA |
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| Platforms (1) |
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| Samples (40)
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| Relations |
| BioProject |
PRJNA952229 |
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