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| Status |
Public on Nov 26, 2023 |
| Title |
Antigen exposure reshapes chromatin architecture in central memory CD8+ T cells and imprints enhanced recall capacity [CUT&RUN] |
| Organism |
Mus musculus |
| Experiment type |
Other
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| Summary |
Compared with naïve CD8+ T cells, antigen-experienced effector and central memory CD8 T cells show extensive CTCF redistribution and 3D genome reorgainzation, which underlie the transcriptomic diversification as well as recall capacity in response to secondary challenges.
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| Overall design |
P14 CD8+ T cells were first transferred into B6.SJL mice followed by LCMV-Arm infection. On day 8 post-infection, KLRG1+IL-7Ra– P14 cells were sorted as effector CD8+ T (Teff) cells, and After ≥30 days, CD62L+ P14 cells were sorted as central memory (Tcm) cells were sorted. The sorted cells were subjected to CTCF CUT&RUN analysis.
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| Contributor(s) |
Xue H, Peng W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 03, 2023 |
| Last update date |
Nov 26, 2023 |
| Contact name |
Shaoqi Zhu |
| E-mail(s) |
zsq.phy@gmail.com
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| Phone |
5714572498
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| Organization name |
the george washington university
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| Street address |
725 21st st nw
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| City |
washington dc |
| State/province |
WASHINGTON |
| ZIP/Postal code |
20052-0051 |
| Country |
USA |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE228887 |
Antigen exposure reshapes chromatin architecture in central memory CD8+ T cells and imprints enhanced recall capacity |
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| Relations |
| BioProject |
PRJNA951780 |
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