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| Status |
Public on Sep 27, 2023 |
| Title |
Enhancing Autophagy in CD11c+ Antigen Presenting Cells as a Therapeutic Strategy for Acute Respiratory Distress Syndrome and Lung Inflammation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the role of autophagy in CD11c+ APCs in a mouse model of Poly(I:C)-induced ALI/ARDS
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| Overall design |
We generated two animal models; mice with a deletion of autophagy-related gene 5 (Atg5) specifically in CD11c+ APCs to impair autophagy and mice with overexpression of transcription factor EB (Tfeb), a regulator of autophagy, in CD11c+ APCs to constitutively induce autophagy.
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| Contributor(s) |
Quach C, Helou DG, Li M, Hurrell BP, Howard E, Shafiei-Jahani P, Soroosh P, Ou JJ, Razani B, Rehan V, Akbari O |
| Citation(s) |
37590140 |
| |
| Submission date |
Mar 13, 2023 |
| Last update date |
Sep 27, 2023 |
| Contact name |
Christine Quach |
| E-mail(s) |
quachc@usc.edu
|
| Organization name |
University of Southern California
|
| Street address |
1450 Biggy St NRT 5509
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90033 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA944147 |
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