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Series GSE22707 Query DataSets for GSE22707
Status Public on Jan 01, 2012
Title Absence of significant overlap in transcriptional patterns between operationally tolerant liver and kidney recipients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Transplant recipients spontaneously accepting their grafts in the absence of immunosuppression demonstrate the feasibility of attaining allograft tolerance in humans. Previous studies have identified blood transcriptional and cell phenotypic markers specific for either liver or kidney tolerant recipients, but the two settings have not been directly compared yet employing the same platforms. To identify potential similarities in immune parameters between recipients tolerant to different organs, we analyzed blood samples from tolerant and non-tolerant liver and kidney recipients employing whole genome expression microarrays. Tolerant and non-tolerant liver and kidney recipients differed in their peripheral blood expression patterns, but no significant overlap was observed between the two datasets. This was confirmed at the functional level by employing gene set enrichment analysis.The lack of obvious similarities in immune parameters associated with liver and kidney tolerant recipients implies the involvement of different mechanisms in the two settings and argues against the existence of a common immunological constant of spontaneous operational tolerance in clinical transplantation.
 
Overall design The complete database comprised the expression measurements of 54,675 genes for liver and kidney trasplant inmunotolerance groups (n=12 for each group).A group of 12 samples from Healthy volunteer are included.
 
Contributor(s) Lozano JJ, Pallier A, Danger R, Martinez-Llordella M, Lopez M, Londoño MC, Rimola A, Soulillou JP, Brouard S, Sanchez-Fueyo A
Citation(s) 21827613
Submission date Jul 05, 2010
Last update date Feb 16, 2021
Contact name Juanjo Lozano
E-mail(s) juanjo.lozano@ciberehd.org
Organization name CIBEREHD
Department Plataforma de Bioinformatica
Street address C/ Rosselló 153
City Barcelona
ZIP/Postal code 08036
Country Spain
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (72)
GSM562612 liver recipients maintaining stable graft function in the absence of immunosuppressive therapy LTOL01
GSM562613 liver recipients maintaining stable graft function in the absence of immunosuppressive therapy LTOL02
GSM562614 liver recipients maintaining stable graft function in the absence of immunosuppressive therapy LTOL03
Relations
BioProject PRJNA128289

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22707_RAW.tar 535.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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