|
| Status |
Public on Aug 01, 2024 |
| Title |
Gene expression changes in mouse breast cancer cells (4T1) after axitinib resistance and FACS isolation of SA-β-galHi (SM+) and SA-β-galLo (SM-) cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequencing analysis was used to identify changes in mouse breast cancer cells (4T1) after axitinib resistance and FACS isolation of SA-β-galHi (SM+) and SA-β-galLo (SM-) cells
|
| |
|
| Overall design |
Mouse breast cancer cells (4T1) resistant to axitinib were derived in vivo after continuous treatment with 100mg/kg/day axitinib from post-surgical lesions. Resistant cells were maintained in vitro with 0.5µM axitinib for more than 2 months. Resistant cells were stained for fluorescent SA-β-gal substrate C12FDG and fractioned into SA-β-galHi (SM+) and SA-β-galLo (SM-) populations
|
| |
|
| Contributor(s) |
Long M, Dolan M, Ebos JM |
| Citation(s) |
38896060 |
| |
| Submission date |
Feb 27, 2023 |
| Last update date |
Aug 01, 2024 |
| Contact name |
Mark D Long |
| E-mail(s) |
mark.long@roswellpark.org
|
| Organization name |
Roswell Park Comprehensive Cancer Center
|
| Department |
Bioinformatics & Biostatistics
|
| Street address |
Elm & Carlton Streets
|
| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14263 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA939225 |
Less...
More...