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GEO accession:
Series GSE224275
Query DataSets for GSE224275
Status
Public on May 10, 2024
Title
Effects on the transcriptome of mouse embryonic fibroblasts after both Son overexpression and knockdown and treatment with 3μM nintedanib, 1μM ponatinib, 3μM proflavine hemisulfate, and 1μM pyrvinium pamoate
Organism
Mus musculus
Experiment type
Expression profiling by high throughput sequencing
Summary
Understanding how genetic and pharmacological effects that change nuclear speckle morphology affect the global transcriptome
Overall design
Comparison of gene expression profiles of mouse embroyonic fibroblasts (MEFs) after genetic manipulation of Son or the aforementioned drug treatments
Contributor(s)
Dion W
,
Liu S
,
Zhu B
Citation(s)
38659924
Submission date
Feb 01, 2023
Last update date
Jun 05, 2024
Contact name
Bokai Zhu
E-mail(s)
bzhu@pitt.edu
Organization name
Aging Institute of UPMC/University of Pittsburgh School of Medicine
Street address
Bridgeside Point 1, 5th Floor, 100 Technology Drive
City
Pittsburgh
State/province
PA
ZIP/Postal code
15219
Country
USA
Platforms (1)
GPL30172
NextSeq 2000 (Mus musculus)
Samples (43)
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GSM7018600
Control siRNA DMSO 1
GSM7018601
Control siRNA DMSO 2
GSM7018602
Control siRNA DMSO 3
GSM7018603
Control siRNA DMSO 4
GSM7018604
Control siRNA tunicamycin 1
GSM7018605
Control siRNA tunicamycin 2
GSM7018606
Control siRNA tunicamycin 3
GSM7018607
Control siRNA tunicamycin 4
GSM7018608
Son siRNA DMSO 1
GSM7018609
Son siRNA DMSO 2
GSM7018610
Son siRNA DMSO 3
GSM7018611
Son siRNA DMSO 4
GSM7018612
Son siRNA tunicamycin 1
GSM7018613
Son siRNA tunicamycin 2
GSM7018614
Son siRNA tunicamycin 3
GSM7018615
Son siRNA tunicamycin 4
GSM7018616
Control sgRNA (CRISPRa) DMSO 1
GSM7018617
Control sgRNA (CRISPRa) DMSO 2
GSM7018618
Control sgRNA (CRISPRa) DMSO 3
GSM7018619
Control sgRNA (CRISPRa) tunicamycin 1
GSM7018620
Control sgRNA (CRISPRa) tunicamycin 2
GSM7018621
Control sgRNA (CRISPRa) tunicamycin 3
GSM7018622
Son sgRNA (CRISPRa) DMSO 1
GSM7018623
Son sgRNA (CRISPRa) DMSO 2
GSM7018624
Son sgRNA (CRISPRa) DMSO 3
GSM7018625
Son sgRNA (CRISPRa) tunicamycin 1
GSM7018626
Son sgRNA (CRISPRa) tunicamycin 2
GSM7018627
Son sgRNA (CRISPRa) tunicamycin 3
GSM7018628
24hr DMSO 1
GSM7018629
24hr DMSO 2
GSM7018630
24hr DMSO 3
GSM7018631
24hr 3μM nintedanib 1
GSM7018632
24hr 3μM nintedanib 2
GSM7018633
24hr 3μM nintedanib 3
GSM7018634
24hr 1μM ponatinib 1
GSM7018635
24hr 1μM ponatinib 2
GSM7018636
24hr 1μM ponatinib 3
GSM7018637
24hr 3μM proflavine hemisulfate 1
GSM7018638
24hr 3μM proflavine hemisulfate 2
GSM7018639
24hr 3μM proflavine hemisulfate 3
GSM7018640
24hr 1μM pyrvinium pamoate 1
GSM7018641
24hr 1μM pyrvinium pamoate 2
GSM7018642
24hr 1μM pyrvinium pamoate 3
Relations
BioProject
PRJNA930441
Download family
Format
SOFT formatted family file(s)
SOFT
MINiML formatted family file(s)
MINiML
Series Matrix File(s)
TXT
Supplementary file
Size
Download
File type/resource
GSE224275_DMSO_and_four_drugs_TPMs.xlsx
3.3 Mb
(ftp)
(http)
XLSX
GSE224275_FPKM_quantification_of_SON_OE_and_KD.xlsx
5.6 Mb
(ftp)
(http)
XLSX
SRA Run Selector
Raw data are available in SRA
Processed data are available on Series record
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