|
| Status |
Public on Jul 25, 2023 |
| Title |
Network analysis reveals strain-dependent response to misfolded tau aggregates |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the effect of wild-derived genetic background on modeling tau aggregation, we injected either AAV-eGFP or AAV-hTauP301L into postnatal day 0 mice to drive widespread expression.
We then performed gene expression profiling analysis using data obtained from mRNA-seq from mouse brain cortex of 6 month old hTauP301L- or eGFP-mice.
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| |
|
| Overall design |
Comparative gene expression profiling analysis of mRNA-seq data for eGFP or hTauP301L mice on the following genetic backgrounds: C57BL6/J, CAST/EiJ, PWK/PhJ, and WSB/EiJ (n=4/background/injection/sex=64).
|
| Web link |
https://doi.org/10.1084/jem.20230180
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| |
|
| Contributor(s) |
Acri DJ, Kim J |
| Citation(s) |
37606887 |
| |
| Submission date |
Jan 26, 2023 |
| Last update date |
Oct 24, 2023 |
| Contact name |
Dominic James Acri |
| E-mail(s) |
dominic.acri@gmail.com
|
| Organization name |
Indiana University School of Medicine
|
| Department |
Stark Neurosciences Research Institute
|
| Lab |
Jungsu Kim Laboratory
|
| Street address |
320 W 15 St, NB Room 107
|
| City |
Indianapolis |
| State/province |
Indiana |
| ZIP/Postal code |
46228 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (64)
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|
| Relations |
| BioProject |
PRJNA928503 |
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