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Series GSE223676 Query DataSets for GSE223676
Status Public on Aug 03, 2023
Title Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Deregulation of the MYC proto-oncogene alters metabolic, translational, cell cycle and other functions in ways that are conducive to tumor induction and maintenance. Myc+/- mice are healthier and age slower than control mice but the long-term ramifications of more complete Myc loss remain unknown. We now describe the life-long consequences of body-wide Myc inactivation initiated post-natally. “MycKO” mice rapidly acquire numerous features of premature aging including altered body composition and habitus, metabolic dysfunction, hepatic steatosis and the dysregulation of numerous gene sets involved in functions that normally deteriorate with aging. Yet, MycKO mice have an extended life span that correlates with a 4-5-fold lower lifetime cancer incidence. Aging tissues from normal mice and humans deregulate many of the same gene sets as do young MycKO mice while also down-regulating Myc and many of its target genes. Aging and its associated cancer predisposition are thus highly coupled via Myc and can be genetically separated.
 
Overall design Comparative gene expression profiling analysis of RNA-seq data for MycKO and WT in 5 month and 20 month old mice's omental adipose tissue, liver and skeletal muscle .
 
Contributor(s) Wang H, Prochownik EV
Citation(s) 37481724, 38976573
Submission date Jan 25, 2023
Last update date Oct 10, 2024
Contact name Huabo Wang
E-mail(s) huw14@pitt.edu
Phone 4126929114
Organization name Children hospital of pittsburgh
Lab Dr. Prochownik lab
Street address 4401 Penn Avenue
City pittsburgh
State/province PA
ZIP/Postal code 15201
Country USA
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (64)
GSM6970617 MycKO 20 month, omental adipose tissue [K18F26]
GSM6970618 MycKO 20 month, omental adipose tissue [K18F27]
GSM6970619 MycKO 20 month, omental adipose tissue [K18F28]
Relations
BioProject PRJNA927272

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Supplementary file Size Download File type/resource
GSE223676_CLC_MycKO_CPM_1_24_23.txt.gz 6.9 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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