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Series GSE223600 Query DataSets for GSE223600
Status Public on Jan 28, 2023
Title Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To investigate the effects of T. cruzi on human cardiomyocytes during infection, we infected induced pluripotent stem cell_x0002_derived cardiomyocytes (iPSC-CM) with the parasite and analyzed responses at 24 hours and 48 hours post infection (hpi) em compared to basal (0hpi - Control) using transcriptomics (RNAseq)
We also validated our finds using RNA-seq data from HIF-1alpha mutated iPSC-CM treated with LPS.
 
Overall design Comparative gene expression profiling analysis of RNA-seq data for iPSC-CM at day 30 after T. cruzi infection
 
Citation(s) 36814444
Submission date Jan 24, 2023
Last update date Mar 09, 2023
Contact name Gabriela Venturini Venturini da Silva
E-mail(s) venturini.gabriela@gmail.com
Organization name Harvard Medical School
Department Department of Genetics
Street address 77 Avenue Louis Pasteur, New Research Bu
City Boston
State/province Massachusetts
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (23)
GSM6965202 iPSC-CM not infected, replicate 1
GSM6965203 iPSC-CM not infected, replicate 2
GSM6965204 iPSC-CM not infected, replicate 3
Relations
BioProject PRJNA926946

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE223600_RAW.tar 68.0 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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