|
| Status |
Public on Feb 01, 2023 |
| Title |
Multimodal decoding of human liver regeneration [st_mouse] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using snRNA-seq combined with spatial profiling of healthy and ALF explant human livers, we uncover a novel migratory hepatocyte subpopulation. We discover a corollary subpopulation in a mouse model of APAP-induced liver regeration, and demonstrate that this subpopulation meidates wound closure following liver injury.
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| |
|
| Overall design |
Spatial transcriptomics was performed on mouse livers along an APAP-induced liver regeneration timecourse.
|
| Web link |
https://www.nature.com/articles/s41586-024-07376-2
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| |
|
| Contributor(s) |
Matchett KP, Portman JR, Kapourani C, Wilson-Kanamori JR, Henderson NC |
| Citation(s) |
38693268 |
| |
| Submission date |
Jan 24, 2023 |
| Last update date |
Jun 25, 2024 |
| Contact name |
John Roger Wilson-Kanamori |
| Organization name |
University of Edinburgh
|
| Department |
Centre for Inflammation Research
|
| Lab |
Henderson
|
| Street address |
47 Little France Crescent
|
| City |
Edinburgh |
| ZIP/Postal code |
EH16 4TJ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (11)
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| This SubSeries is part of SuperSeries: |
| GSE223561 |
Multimodal decoding of human liver regeneration |
|
| Relations |
| BioProject |
PRJNA927113 |
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