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Series GSE223560 Query DataSets for GSE223560
Status Public on Feb 01, 2023
Title Multimodal decoding of human liver regeneration [st_mouse]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Using snRNA-seq combined with spatial profiling of healthy and ALF explant human livers, we uncover a novel migratory hepatocyte subpopulation. We discover a corollary subpopulation in a mouse model of APAP-induced liver regeration, and demonstrate that this subpopulation meidates wound closure following liver injury.
 
Overall design Spatial transcriptomics was performed on mouse livers along an APAP-induced liver regeneration timecourse.
Web link https://www.biorxiv.org/content/10.1101/2023.02.24.529873v1
 
Contributor(s) Matchett KP, Portman JR, Kapourani C, Wilson-Kanamori JR, Henderson NC
Citation(s) 38693268
Submission date Jan 24, 2023
Last update date May 02, 2024
Contact name John Roger Wilson-Kanamori
Organization name University of Edinburgh
Department Centre for Inflammation Research
Lab Henderson
Street address 47 Little France Crescent
City Edinburgh
ZIP/Postal code EH16 4TJ
Country United Kingdom
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (11)
GSM6963514 Healthy_liver_spatial_002
GSM6963515 Healthy_liver_spatial_003
GSM6963517 Healthy_liver_spatial_004
This SubSeries is part of SuperSeries:
GSE223561 Multimodal decoding of human liver regeneration
Relations
BioProject PRJNA927113

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Supplementary file Size Download File type/resource
GSE223560_RAW.tar 1.7 Gb (http)(custom) TAR (of CSV, JPG, JSON, MTX, PNG, TIFF, TSV)
GSE223560_seurat_object.rds.gz 371.3 Mb (ftp)(http) RDS
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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