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| Status |
Public on Sep 15, 2023 |
| Title |
Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence [scRNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Single cell transcriptomics and functional assessment in a stage-specific manner provides a comprehensive comparison of entire female germ cell development in vitro and in vivo.
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| |
|
| Overall design |
To identify possible causes underlying the overall low oogenic and embryonic competence of in vitro developed oocytes, we performed extensive comparative transcriptome analysis between in vivo and in vitro generated germ cells, at different stages of their development.
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| |
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| Contributor(s) |
Aizawa E, Ozonov EA, Kawamura YK, Peters AH, Wutz A |
| Citation(s) |
37850882 |
| |
| Submission date |
Jan 23, 2023 |
| Last update date |
Dec 13, 2023 |
| Contact name |
Antoine Peters |
| E-mail(s) |
Antoine.Peters@fmi.ch
|
| Organization name |
Friedrich Miescher Institute
|
| Street address |
Maulbeerstrasse 66
|
| City |
Basel |
| ZIP/Postal code |
4058 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (163)
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| This SubSeries is part of SuperSeries: |
| GSE223479 |
Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence |
|
| Relations |
| BioProject |
PRJNA926507 |
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