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Status |
Public on Jul 08, 2011 |
Title |
Gene expression profiling of early primary breast cancer to identify prognostic markers and associated pathways |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Retrospective series of primary breast cancer patients who received surgery between 1989 and 1992. Patients received adjuvant chemotherapy and/or adjuvant hormone therapy, or no adjuvant treatment. Tamoxifen was used as endocrine therapy for 5 years in ER+ BC patients. Patients who were <50 years of age, with lymph node positive tumors, or ER– and/or >3 cm in diameter, received adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) for six cycles, in a thrice weekly intravenous regimen. Patients >50 years of age with ER–, lymph node–positive tumors also received CMF.
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Overall design |
Retrospective clinical study to identify breast cancer prognostic markers and associated pathways. 216 early primary breast cancers were considered who had complete 10-years follow-up, clinical and demographics information. mRNA profiling data.
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Contributor(s) |
Buffa FM, Winchester L |
Citation(s) |
21737487 |
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Submission date |
Jun 08, 2010 |
Last update date |
Jan 29, 2013 |
Contact name |
Francesca Buffa |
E-mail(s) |
francesca.buffa@imm.ox.ac.uk
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Organization name |
University of Oxford
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Street address |
The Weatherall Institute of Molecular Medicine
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City |
Oxford |
ZIP/Postal code |
OX3 9DS |
Country |
United Kingdom |
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Platforms (1) |
GPL6098 |
Illumina humanRef-8 v1.0 expression beadchip |
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Samples (216)
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This SubSeries is part of SuperSeries: |
GSE22220 |
Analysis of early primary breast cancer to identify prognostic markers and associated pathways: mRNA and miRNA profiling |
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Relations |
BioProject |
PRJNA129185 |