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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 10, 2023 |
| Title |
Transcriptome profiling of phagocytic or non-phagocytic microglia from Ifngr1 cKO mice. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Investigate the effect of depleting Ifngr1 in microglia on their response to acute neurodegeneration
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| Overall design |
Apoptotic neurons were stereotaxically injected into the cortex and hippocampus of WT and Ifngr1 cKO mice. After 16 hours, phagocytic/non-phagocytic microglia were sorted for RNAseq.
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| Contributor(s) |
Zhuoran Y, Shawn H, Silveira S, Gauthier C, Mallah D, Kleemann K, Cheng C, Margeta MA, Pitts KM, Barry J, Shorey H, Brandao W, Durao A, Christophe Delpech J, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O |
| Citation(s) |
37291336 |
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| Submission date |
Dec 15, 2022 |
| Last update date |
Jul 11, 2023 |
| Contact name |
Zhuoran Yin |
| E-mail(s) |
zhuoranyin01@gmail.com
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| Phone |
9293199918
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| Organization name |
Brigham and Women's Hospital
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| Department |
Neurology
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| Street address |
60 Fenwood Road
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| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE205569 |
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease |
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| Relations |
| BioProject |
PRJNA912714 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE221080_RAW.tar |
17.2 Mb |
(http)(custom) |
TAR (of TAR) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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