|
| Status |
Public on Feb 08, 2023 |
| Title |
Excitotoxic glutamate levels drive spinal cord ependymal stem cell proliferation and fate specification through CP-AMPAR signaling |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The adult spinal cord contains a population of ependymal-derived neural stem/progenitor cells (epNSPCs) that are normally quiescent, but are activated to proliferate, differentiate, and migrate after spinal cord injury. The mechanisms that regulate their response to injury cues, however, remain unknown. Here, we demonstrate that excitotoxic levels of glutamate promote the proliferation and astrocytic fate specification of adult spinal cord epNSPCs through CP-AMPAR signaling.
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| |
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| Overall design |
Bulk RNA-sequencing on rat epNSPCs in the presence and absence of excitotoxic levels of glutamate in vitro.
|
| Web link |
https://pubmed.ncbi.nlm.nih.gov/36764296/
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| |
|
| Contributor(s) |
Hachem LD, Hong J, Velumian A, Mothe AJ, Tator CH, Fehlings MG |
| Citation(s) |
36764296 |
| |
| Submission date |
Dec 14, 2022 |
| Last update date |
May 10, 2023 |
| Contact name |
Michael Fehlings |
| E-mail(s) |
michael.fehlings@uhn.ca
|
| Organization name |
University Health Network
|
| Department |
Genetics and Development
|
| Street address |
60 Leonard Avenue, 7KD-430
|
| City |
Toronto |
| State/province |
ON |
| ZIP/Postal code |
M5T 2S8 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA912215 |
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