|
| Status |
Public on Dec 12, 2022 |
| Title |
Telomere-to-mitochondria signaling by ZBP1 mediates replicative crisis (RNA-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Transcriptional response to telomere shortening or dysfunction
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| |
|
| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for growing and crisis IMR90E6E7 (3 replicates each); growing and crisis WI38SV40LT (3 replicates each), pre-crisis IMR90E6E7 transfected with non-targeting siRNA (control) or two individual siRNAs against ZBP1 (3 replicates each), growing IMR90E6E7 expressing either a dox-inducible TRF1(DN) or dox-inducible VP16-TRF1(DN) and constitutive expression of either ZBP1(S)WT-Flag or ZBP1(S)DZa2-Flag (3 replicates each), and pre-crisis IMR90E6E7 expressing GFP-targeting gRNA (control), MAVS-targeting gRNA, or STING-targeting gRNA (2 replicates each).
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| |
|
| Contributor(s) |
Nassour J, Karlseder J |
| Citation(s) |
36755096 |
| |
| Submission date |
Nov 20, 2022 |
| Last update date |
Aug 21, 2023 |
| Contact name |
Jingting Yu |
| Organization name |
Salk Institute for Biological Studies
|
| Street address |
10010 N Torrey Pines Rd
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (39)
|
|
| This SubSeries is part of SuperSeries: |
| GSE218396 |
Telomere-to-mitochondria signaling by ZBP1 mediates replicative crisis |
|
| Relations |
| BioProject |
PRJNA903485 |
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