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Status |
Public on Jun 15, 2024 |
Title |
Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We tested the hypothesis that increase dosage of Ube3a may exert its influence on transcriptomic organization in a sex-biased manner
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Overall design |
We performed gene expression analysis using data obtained from RNA-seq of prefrontal cortex and hypothalamus dissected from adult male and female mice with extra copies of Ube3a (Ube3a2x) and Wild-type controls
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Contributor(s) |
Montani C, Balasco L, Lau P, Provenzano G, Bozzi Y, Lombardo MV, Gozzi A |
Citation(s) |
38996019 |
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Submission date |
Nov 07, 2022 |
Last update date |
Sep 18, 2024 |
Contact name |
Caterina Montani |
Organization name |
IIT - Istituto Italiano di Tecnologia
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Street address |
Corso Bettini 31
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City |
Rovereto |
ZIP/Postal code |
38068 |
Country |
Italy |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (38)
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GSM6717060 |
245, Prefrontal cortex, WT, Male |
GSM6717061 |
251, Hypothalamus, WT, Male |
GSM6717062 |
251, Prefrontal cortex, WT, Male |
GSM6717063 |
253, Hypothalamus, Ube3a2x, Male |
GSM6717064 |
253, Prefrontal cortex, Ube3a2x, Male |
GSM6717065 |
256, Prefrontal cortex, WT, Male |
GSM6717066 |
258, Hypothalamus, Ube3a2x, Male |
GSM6717067 |
258, Prefrontal cortex, Ube3a2x, Male |
GSM6717068 |
259, Prefrontal cortex, WT, Female |
GSM6717069 |
262, Hypothalamus, WT, Female |
GSM6717070 |
262, Prefrontal cortex, WT, Female |
GSM6717071 |
266, Prefrontal cortex, WT, Male |
GSM6717072 |
267, Hypothalamus, Ube3a2x, Male |
GSM6717073 |
267, Prefrontal cortex, Ube3a2x, Male |
GSM6717074 |
272, Hypothalamus, Ube3a2x, Female |
GSM6717075 |
272, Prefrontal cortex, Ube3a2x, Female |
GSM6717076 |
395, Prefrontal cortex, WT, Female |
GSM6717077 |
397, Prefrontal cortex, WT, Female |
GSM6717078 |
398, Hypothalamus, WT, Female |
GSM6717079 |
402, Prefrontal cortex, Ube3a2x, Male |
GSM6717080 |
403, Hypothalamus, WT, Male |
GSM6717081 |
403, Prefrontal cortex, WT, Male |
GSM6717082 |
404, Hypothalamus, Ube3a2x, Male |
GSM6717083 |
410, Hypothalamus, WT, Female |
GSM6717084 |
417, Hypothalamus, Ube3a2x, Female |
GSM6717085 |
417, Prefrontal cortex, Ube3a2x, Female |
GSM6717086 |
420, Hypothalamus, Ube3a2x, Female |
GSM6717087 |
420, Prefrontal cortex, Ube3a2x, Female |
GSM6717088 |
423, Hypothalamus, WT, Male |
GSM6717089 |
462, Hypothalamus, Ube3a2x, Female |
GSM6717090 |
462, Prefrontal cortex, Ube3a2x, Female |
GSM6717091 |
468, Hypothalamus, Ube3a2x, Female |
GSM6717092 |
468, Prefrontal cortex, Ube3a2x, Female |
GSM6717093 |
471, Hypothalamus, WT, Female |
GSM6717094 |
93, Prefrontal cortex, WT, Female |
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Relations |
BioProject |
PRJNA898989 |
Supplementary file |
Size |
Download |
File type/resource |
GSE217420_Montani_Pagani_et_al_RNAseq_quality_control_parameters.csv.gz |
7.0 Kb |
(ftp)(http) |
CSV |
GSE217420_reads_processed_all_samples.csv.gz |
2.7 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
Raw data are available in SRA |
Processed data are available on Series record |
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