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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 24, 2022 |
| Title |
The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Methods: To characterize the expression profile of ERF-CIC deleted prostate cells, we performed single-cell RNA-sequencing of PNT2 ERF knock down and CIC knockout cell line.
Results: We found that CIC and ERF loss were significantly associated with the ETV1-regulated gene set but was anti-correlated with the TMPRSS2-ERG fusion signature gene set. The enrichment gene signature of ERF-CIC dual loss was similar to ERF loss alone and ETV1-regulated gene set signature.
Conclusions: Our results provide relevant insights about a new subtype of prostate cancer with ERF and CIC codeletion
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| Overall design |
RNA sequencing of CIC-ERF codeletion in PNT2, CICKO and ERF KD in PNT2 cells
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| Contributor(s) |
Gupta N, Song H, Xu W, Ponce RK, Lin YK, Kim JW, Small EJ, Feng FY, Huang FW, Okimoto RA |
| Citation(s) |
36383412 |
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| Submission date |
Oct 21, 2022 |
| Last update date |
Nov 29, 2022 |
| Contact name |
Hanbing Song |
| E-mail(s) |
hanbing.song@ucsf.edu
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| Organization name |
UCSF
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| Street address |
513 Parnassus Ave.
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| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA892983 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE216318_RAW.tar |
19.0 Mb |
(http)(custom) |
TAR (of TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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