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| Status |
Public on Oct 20, 2022 |
| Title |
JAK2V617F-dependent clonal hematopoiesis drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In order to understand the mechanisms responsible for lethal JAK2V617F-dependent aortic disease, we performed RNA sequencing in the aorta of 7-week old Jak2V617F HC-EC and control Jak2WT mice
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| Overall design |
Bulk aorta RNA-seq analysis from 7-week old mice with a JAK2V617F mutation or their wild-type littermates.
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| Contributor(s) |
Al-Rifai R, Ait-Oufella H, Diedisheim M |
| Citation missing |
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| |
| Submission date |
Oct 13, 2022 |
| Last update date |
Oct 23, 2022 |
| Contact name |
Hafid Ait-Oufella |
| E-mail(s) |
hafid.aitoufella@inserm.fr
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| Phone |
+33612011940
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| Organization name |
Inserm
|
| Department |
U970
|
| Street address |
56, Rue Leblanc
|
| City |
Paris |
| ZIP/Postal code |
75015 |
| Country |
France |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA890296 |
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