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Status |
Public on Oct 20, 2022 |
Title |
JAK2V617F-dependent clonal hematopoiesis drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
In order to understand the mechanisms responsible for lethal JAK2V617F-dependent aortic disease, we performed RNA sequencing in the aorta of 7-week old Jak2V617F HC-EC and control Jak2WT mice
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Overall design |
Bulk aorta RNA-seq analysis from 7-week old mice with a JAK2V617F mutation or their wild-type littermates.
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Contributor(s) |
Al-Rifai R, Ait-Oufella H, Diedisheim M |
Citation missing |
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Submission date |
Oct 13, 2022 |
Last update date |
Oct 23, 2022 |
Contact name |
Hafid Ait-Oufella |
E-mail(s) |
hafid.aitoufella@inserm.fr
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Phone |
+33612011940
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Organization name |
Inserm
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Department |
U970
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Street address |
56, Rue Leblanc
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City |
Paris |
ZIP/Postal code |
75015 |
Country |
France |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (10)
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Relations |
BioProject |
PRJNA890296 |