|
| Status |
Public on Jan 25, 2023 |
| Title |
Exogenous SLFN12 reduces in vivo TNBC proliferation and invasion, increases luminal markers and a gene signature that reducts better breast cancer survival in cohort database analysis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our results suggest that increased SLFN12 expression modulates TNBC aggressiveness through a gene signature which could offer new targets for treatment.
|
| |
|
| Overall design |
Human TNBC tumor xenografts with exogenous SLFN12 expression were created and the growth was observed and then RNA-seq was performed to investigate pathways related to SLFN12
|
| |
|
| Contributor(s) |
Singhal S, Al-Marsoummi S, Vomhof-DeKrey EE, Lauckner B, Beyer T, Basson MD |
| Citation(s) |
36672349 |
| |
| Submission date |
Oct 13, 2022 |
| Last update date |
Jan 26, 2023 |
| Contact name |
Marc D Basson |
| E-mail(s) |
marc.basson@und.edu
|
| Organization name |
University of North Dakota
|
| Street address |
1301 N Columbia Rd
|
| City |
Grand Forks |
| State/province |
ND |
| ZIP/Postal code |
58203 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA890280 |
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