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| Status |
Public on Jan 30, 2023 |
| Title |
Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
To assess their utility in routine neuropathology, we prospectively integrated DNA methylation-based CNS tumor classification and targeted gene panel sequencing of tumor and constitutional DNA with blinded neuropathological reference diagnostics for a population-based cohort of > 1,200 newly-diagnosed pediatric patients.
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| Overall design |
CNS tumor samples from 1,124 patients ≤21 years were profiled using the Illumina Infinium HumanMethylation450 (n = 187) and MethylationEPIC (n = 937) BeadChip arrays at the time of primary diagnosis.
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| Web link |
https://rdcu.be/dbfPu
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| Contributor(s) |
Sturm D, Capper D, Andreiuolo F, Gessi M, Sill M, Koelsche C, Reinhardt A, Sievers P, Wefers AK, Ebrahimi A, Suwala AK, Gielen GH, Schrimpf D, Stichel D, Hovestadt V, Daenekas B, Rode A, Hamelmann S, Previti C, Jäger N, Buchhalter I, Blattner-Johnson M, Jones BC, Warmuth-Metz M, Bison B, Hasselblatt M, Schüller U, Grund K, Sutter C, Hirsch S, Dikow N, Gerber NU, White CL, Buntine MK, Kinross K, Algar EM, Hansford JR, Gottardo NG, Hernáiz Driever P, Gnekow A, Witt O, Müller HL, Calaminus G, Fleischhack G, Kordes U, Mynarek M, Rutkowski S, Frühwald MC, Kramm CM |
| Citation(s) |
36928815 |
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| Submission date |
Oct 11, 2022 |
| Last update date |
Sep 23, 2024 |
| Contact name |
Martin Sill |
| E-mail(s) |
m.sill@dkfz.de
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| Organization name |
DKFZ
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| Department |
Division of Pediatric Neurooncology
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| Street address |
Im Neuenheimer Feld 280
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| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (2) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
| GPL21145 |
Infinium MethylationEPIC |
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| Samples (1124)
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| Relations |
| BioProject |
PRJNA889441 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE215240_RAW.tar |
14.9 Gb |
(http)(custom) |
TAR (of IDAT) |
| GSE215240_betas_preprocessed_GPL13534.txt.gz |
722.7 Mb |
(ftp)(http) |
TXT |
| GSE215240_betas_preprocessed_GPL21145.txt.gz |
6.2 Gb |
(ftp)(http) |
TXT |
| GSE215240_betas_preprocessed_combined_probes_from_both_platforms.txt.gz |
426.6 Mb |
(ftp)(http) |
TXT |
| Processed data are available on Series record |
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