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| Status |
Public on Oct 03, 2023 |
| Title |
Gene expression profile analysis of the molecular mechanism of HOXD10 regulating epithelial ovarian cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer. Although studies have reported that downregulation of HOXD10 expression may contribute to the migration and invasion abilities in EOC, much remains to be fully elucidated. The present study aimed to identify different gene expression profiles of HOXD10 overexpression from the Human OneArray microarray and bioinformatics for the regulation of the progression of EOC cells. Bioinformatics analysis revealed that the pathways of the genes with different expressions were related to oxidative phosphorylation and mitochondrial function. Although the detailed regulatory mechanism between HOXD10 and the targeted oxidative phosphorylation genes is not yet fully understood, the findings of the present provide novel insight on HOXD10-mediated pathways for cancer metabolism, carcinogenesis, and the progression of EOC.
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| |
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| Overall design |
Examination of HOXD10 in TOV112D
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| |
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| Contributor(s) |
Hsu CY, Tsai CC, Lo HW, Ou YC, Lin HY, Chen HL, Tsai EM |
| Citation(s) |
38356716 |
| |
| Submission date |
Oct 06, 2022 |
| Last update date |
Feb 26, 2024 |
| Contact name |
ChiaYi Hsu |
| Organization name |
Kaohsiung Medical University
|
| Department |
Graduate Institute of Medicine, College of Medicine
|
| Street address |
No. 100, Shih-Chung 1
|
| City |
Kaohsiung |
| State/province |
State... |
| ZIP/Postal code |
80708 |
| Country |
Taiwan |
| |
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| Platforms (1) |
| GPL21282 |
Phalanx Human OneArray Ver. 7 Release 1 |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA887729 |
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