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| Status |
Public on Sep 27, 2022 |
| Title |
CXCR1 and Its Downstream NF-κB Inflammation Signaling Pathway as a Key Target of Guanxinning Injection for Myocardial Ischemia/reperfusion Injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the therapeutic effect of Guanxinning injection (GXNI) on myocardial ischemia/reperfusion injury (MIRI) mice, we established MIRI model by ligating the left anterior descending (LAD) coronary artery of mice for 30 minutes and then reperfusion for 24 hours. We then performed RNA-seq on myocardial tissue of mice in the sham group, MIRI group and GXNI treatment group.
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| Overall design |
The significant differential expressed genes were analyzed in myocardial tissue of mice in the sham group, MIRI group and GXNI treatment group.
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| Contributor(s) |
Xiao G, Lyu M, Zhu Y |
| Citation(s) |
36325326 |
| |
| Submission date |
Sep 24, 2022 |
| Last update date |
Jun 30, 2023 |
| Contact name |
Guangxu Xiao |
| E-mail(s) |
xgxx123456@126.com
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| Organization name |
Tianjin University of Traditional Chinese Medicine
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| Street address |
Beihua South Road, JingHai District
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| City |
Tianjin |
| ZIP/Postal code |
301617 |
| Country |
China |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA883980 |
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