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Series GSE213554 Query DataSets for GSE213554
Status Public on Jan 26, 2024
Title A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Genome-wide DNA Methylation array on iPSCs and organoids with different genetic mutations.
 
Overall design DNA methylation array on organoids with Illumina Infinium MethylationEPIC array. Samples include 1-, 2- and 3-month-old organoids from WT (wildtype), PT (PTEN-/-; TP53-/-), PTCC (PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-), and PTN (PTEN-/-; TP53-/-; NF1-/-) samples. Four replicates for 3-month-old PT, PTCC and PTN organoids, and three replicates for the rest of the groups. DNA methylation array on organoids with Illumina Infinium HumanMethylation450 array. Samples include human iPSC cell line and 2-month-old organoids from WT (wildtype), PT (PTEN-/-; TP53-/-), PTCC (PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-), and PTN (PTEN-/-; TP53-/-; NF1-/-) samples (Three replicates in each group).
 
Contributor(s) Liu H, Wang C
Citation(s) 38273014
Submission date Sep 16, 2022
Last update date Jan 27, 2024
Contact name Haikun Liu
E-mail(s) l.haikun@dkfz.de
Organization name DKFZ
Street address INF 581
City Heidelberg
ZIP/Postal code 69120
Country Germany
 
Platforms (2)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
GPL23976 Illumina Infinium HumanMethylation850 BeadChip
Samples (75)
GSM6589011 organoids_1-month-old-WT_rep1
GSM6589012 organoids_1-month-old-WT_rep2
GSM6589013 organoids_1-month-old-WT_rep3
Relations
BioProject PRJNA881325

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE213554_RAW.tar 1.2 Gb (http)(custom) TAR (of IDAT)
Processed data included within Sample table
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