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| Status |
Public on May 01, 2023 |
| Title |
Nono deficiency impedes the proliferation and adhesion of H9c2 cardiomyocytes through Pi3k/Akt signaling pathway [ATAC-seq] |
| Organism |
Rattus norvegicus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Purpose: Congenital heart disease (CHD) is the most common type of birth defect and the main noninfectious cause of death during the neonatal stage. Currently, hemizygous loss-of-function variants in NONO(The non-POU domain containing, octamer-binding) gene have been described as the cause of congenital heart defects in males. However, the effects of NONO on cardiac development have not been fully elucidated.
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| Overall design |
Rat cardiomyocytes H9c2 mRNA profiles and chromatin accessibility across the genome in wild type group and Nono gene knockout group
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| |
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| Contributor(s) |
Lei Y, Cao H, Wang X |
| Citation(s) |
37130848 |
| |
| Submission date |
Aug 16, 2022 |
| Last update date |
Jul 31, 2023 |
| Contact name |
Xinrui Wang |
| E-mail(s) |
wanxiru@sjtu.edu.cn
|
| Organization name |
Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
|
| Street address |
197 Ruijin Rd II
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| City |
Shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
| |
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| Platforms (1) |
| GPL24688 |
HiSeq X Ten (Rattus norvegicus) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE211404 |
Nono deficiency impedes the proliferation and adhesion of H9c2 cardiomyocytes through Pi3k/Akt signaling pathway |
|
| Relations |
| BioProject |
PRJNA870109 |
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