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Series GSE21107 Query DataSets for GSE21107
Status Public on Dec 02, 2010
Title NF1 inactivation in adult acute myelogenous leukemia
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML).

Conclusions: NF1 null states are present in 7/95=7% of adult AML and delineate a disease subset that could be preferentially targeted by Ras or mTOR-directed therapeutics.
 
Overall design Experimental design: We analyzed DNA from highly purified AML blasts and paired buccal cells from 95 patients for recurrent genomic microdeletions using ultra-high density Affymetrix SNP 6.0 array-based genomic profiling.
006, 096 and 136 normal Samples have been excluded from study.
 
Contributor(s) Parkin B, Ouillette P, Wang Y, Liu Y, Wright W, Roulston D, Purkayastha A, Dressel A, Karp J, Bockenstedt P, Al-Zoubi A, Talpaz M, Kujawski L, Liu Y, Shedden K, Shakhan S, Li C, Erba H, Malek SN
Citation(s) 20505189
Submission date Mar 29, 2010
Last update date Nov 27, 2018
Contact name Sami N Malek
E-mail(s) smalek@med.umich.edu, pouillet@med.umich.edu
Phone 734-763-1222
Organization name University of Michigan
Department Internal Medicine, Hematology-Oncology
Street address 4410 Cancer Center; 1500 E Medical Center Dr
City Ann Arbor
State/province MI
ZIP/Postal code 48109
Country USA
 
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (187)
GSM527666 MIAML005N_primary human: buccal
GSM527667 MIAML005T_primary human: blood or bone marrow, FACS sort-purified AML blasts
GSM527668 MIAML006T_primary human: blood or bone marrow, FACS sort-purified AML blasts
Relations
BioProject PRJNA126677

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE21107_RAW.tar 6.4 Gb (http)(custom) TAR (of CEL, TXT)
Processed data included within Sample table
Processed data provided as supplementary file
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