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| Status |
Public on Sep 13, 2023 |
| Title |
NFE2L3 Drives Hepatocellular Carcinoma Proliferation via Regulating the Proteasome-Dependent Degradation of ISGylation p53 through interaction with TRIM25. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the function of NFE2L3 and NFE2L3△C(557-694aa) in the regulation of hepatocellular carcinoma proliferation, we established HepG2 cell lines in which the target gene has been over express by lentiviruses.
We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different cells at three-time points.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for HepG2 cell derivatives (lvNC, lvNFE2L3, and lvNFE2L3△C(557-694aa)).
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| Contributor(s) |
Yonggang R, Jing Y |
| Citation(s) |
37350063 |
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| Submission date |
Aug 09, 2022 |
| Last update date |
Sep 13, 2023 |
| Contact name |
Yongang Ren |
| E-mail(s) |
rygqfyy@nsmc.edu.cn
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| Organization name |
North Sichuan Medical College
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| Street address |
No. 55 Dongshun Road, Gaoping District, Nanchong, Sichuan
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| City |
Nanchong |
| State/province |
Sichuan |
| ZIP/Postal code |
637000 |
| Country |
China |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (9)
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| GSM6438115 |
HepG2 cells, lvN3, Day0 |
| GSM6438116 |
HepG2 cells, lvN3, Day3 |
| GSM6438117 |
HepG2 cells, lvN3, Day6 |
| GSM6438118 |
HepG2 cells, lvN3D, Day0 |
| GSM6438119 |
HepG2 cells, lvN3D, Day3 |
| GSM6438120 |
HepG2 cells, lvN3D, Day6 |
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| Relations |
| BioProject |
PRJNA867580 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE210803_GeneExpr.Count.FPKM.xlsx |
5.9 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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