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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 24, 2023 |
| Title |
Tissue-resident memory T-cells in pancreatic ductal adenocarcinoma co-express PD-1 and TIGIT and inhibition is reversible by dual antibody blockade |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
An in-depth investigation of the pancreatic ductal adenocarcinoma tumour microenvironment highlights PD-1 and TIGIT, or their corresponding ligands, as potential targets for combinatorial monoclonal antibody therapy to treat this devastating disease.
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| Overall design |
Single Cell RNA profile of cells in the PDAC tumor microenvironment
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| Contributor(s) |
Pearce H, Croft W, Nicol S, Margielewska-Davies S, Powell R, Cornall R, Davis SJ, Marcon F, Pugh M, Fennell É, Powell-Brett S, Brown R, Middleton G, Mahon B |
| Citation(s) |
36689623, 37350578 |
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| Submission date |
Aug 01, 2022 |
| Last update date |
Sep 12, 2023 |
| Contact name |
Paul Moss |
| Organization name |
University of Birmingham
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| Department |
Immunology and Immunotherapy
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| Lab |
Moss
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| Street address |
Vincent Drive
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| City |
Birmingham |
| State/province |
West Midlands |
| ZIP/Postal code |
B152TT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA864758 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE210199_counts.csv.gz |
202.1 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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