|
| Status |
Public on Dec 01, 2023 |
| Title |
Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the transfer of alpha-s-ynuclein aggregates from neurons to microglia and examined transcriptomic changes following protein extraction. By obtaining RNA samples, we performed differential expression analysis and generated gene ontology enrichment and network analysis.
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| |
|
| Overall design |
mRNA sequencing of Neurons from mice treated with and without aSyn cocultured in the presence of microglia
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| |
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| Contributor(s) |
Scheiblich H, Eikens F, Wischhof L, Opitz S, Jüngling K, Cserép C, Schmidt SV, Bellande T, Pósfai B, Geck C, Spitzer J, Odainic A, Schwartz S, Di Monte DA, Bano D, Dénes Á, Latz E, Melki R, Pape H, Heneka MT |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 28, 2022 |
| Last update date |
Dec 01, 2023 |
| Contact name |
Susanne Schmidt |
| E-mail(s) |
Susanne.Schmidt@uni-bonn.de
|
| Phone |
+4922828712102
|
| Organization name |
University Hospital Bonn
|
| Department |
Institute of Clin. Chemistry and Clin. Pharmacology
|
| Lab |
Immune Monitoring & Genomics
|
| Street address |
Venusberg-Campus 1
|
| City |
Bonn |
| ZIP/Postal code |
53127 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (16)
|
| GSM6411905 |
Neurons_single_aSyn [DE39NGSUKBR117811] |
| GSM6411906 |
Neurons_single_aSyn [DE44NGSUKBR117818] |
| GSM6411907 |
Neurons_single_aSyn [DE49NGSUKBR117825] |
| GSM6411908 |
Neurons_single_aSyn [DE54NGSUKBR117832] |
| GSM6411909 |
Neurons_coculture_aSyn [DE55NGSUKBR117814] |
| GSM6411910 |
Neurons_coculture_aSyn [DE60NGSUKBR117821] |
| GSM6411911 |
Neurons_coculture_aSyn [DE65NGSUKBR117828] |
| GSM6411912 |
Neurons_single_wo [DE66NGSUKBR117810] |
| GSM6411913 |
Neurons_coculture_aSyn [DE70NGSUKBR117835] |
| GSM6411914 |
Neurons_single_wo [DE71NGSUKBR117817] |
| GSM6411915 |
Neurons_single_wo [DE76NGSUKBR117824] |
| GSM6411916 |
Neurons_single_wo [DE81NGSUKBR117831] |
| GSM6411917 |
Neurons_coculture_wo [DE82NGSUKBR117813] |
| GSM6411918 |
Neurons_coculture_wo [DE87NGSUKBR117820] |
| GSM6411919 |
Neurons_coculture_wo [DE92NGSUKBR117827] |
| GSM6411920 |
Neurons_coculture_wo [DE97NGSUKBR117834] |
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| This SubSeries is part of SuperSeries: |
| GSE209972 |
Microglia care for neurons through tunneling nanotubes |
|
| Relations |
| BioProject |
PRJNA863252 |
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