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Series GSE209859 Query DataSets for GSE209859
Status Public on Aug 17, 2022
Title Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Psilocybin, and other serotonergic psychedelics, have re-emerged as therapeutics for neuropsychiatric disorders, including addiction. Psilocybin induces long-lasting effects on behavior, likely due to its profound ability to alter consciousness and augment neural connectivity and plasticity. Impaired synaptic plasticity in obesity contributes to ‘addictive-like’ behaviors, including heightened motivation for palatable food, and excessive food seeking and consumption. Here, we evaluate the effects of psilocybin on feeding behavior, energy metabolism and as a weight-lowering agent in mice. We demonstrate that a single dose of psilocybin substantially alters the prefrontal cortex transcriptome but has no acute or long-lasting effects on food intake or body weight in diet-induced obese mice or in genetic mouse models of obesity. Similarly, sub-chronic microdosing of psilocybin has no metabolic effects in obese mice and psilocybin does not augment glucagon-like peptide-1 (GLP-1) induced weight loss or enhance diet-induced weight loss. A single high dose of psilocybin reduces sucrose preference but fails to counter binge-like eating behavior. Although these preclinical data discourage clinical investigation, there may be nuances in the mode of action of psychedelic drugs that are difficult to capture in rodent models, and thus require human evaluation to uncover.
 
Overall design Two-way ANOVA like setup in two brain regions: Hypothalamus and Frontal Cortex. The effect of Psilocybin injection is compared to saline injection at two timepoints: 3 hours post injection and 4 weeks post injection.
 
Contributor(s) Fadahunsi N, Lund J, Wollesen Breum A, Vad Mathiesen C, Beck Larsen I, Moos Knudsen G, Bue Klein A, Clemmensen C
Citation(s) 35953488
Submission date Jul 27, 2022
Last update date Aug 17, 2022
Contact name Lars Roed Ingerslev
E-mail(s) ingerslev@sund.ku.dk
Organization name Copenhagen University
Department NNF Center for Basic Metabolic Research
Lab Integrative Physiology
Street address Blegdamsvej 3B
City Copenhagen
ZIP/Postal code 2200
Country Denmark
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (64)
GSM6402563 Hypothalamus_Psilocybin_3-hours-post-injection_1
GSM6402564 Hypothalamus_Psilocybin_3-hours-post-injection_2
GSM6402565 Hypothalamus_Psilocybin_3-hours-post-injection_3
Relations
BioProject PRJNA862729

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Supplementary file Size Download File type/resource
GSE209859_counts.csv.gz 3.3 Mb (ftp)(http) CSV
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Processed data are available on Series record
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