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| Status |
Public on Jul 26, 2022 |
| Title |
Interleukin-1b in Tendon Injury Enhances Reparative Gene and Protein Expression in Mesenchymal Stem Cells |
| Organism |
Equus caballus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Intralesional mesenchymal stem cell (MSC) therapy has improved tissue architecture and reinjury rates in equine tendon injury; however, the mechanisms by which they promote repair are still being investigated.
Therefore, the objectives of this study were to determine how the predominate pro-inflammatory cytokines present in a surgically induced model of equine tendon injury modulate MSC gene and protein expression.
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| Overall design |
Comparative gene expression analysis (RNA-seq) of paired (naïve or licensed) equine mesenchymal stem cells (n=6) following IL-1b or IL-6 licensing.
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| Contributor(s) |
Koch DW, Schnabel LV |
| Citation(s) |
36032300 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| T32 OD011130 |
Comparative Medicine and Translational Research Training Program |
NORTH CAROLINA STATE UNIVERSITY |
Samuel L Jones |
| K01 OD027037 |
Manipulation of MHC expression using TGF-beta2 to reduce mesenchymal stem cell immunogenicity |
NORTH CAROLINA STATE UNIVERSITY |
Alix K. Berglund |
| T35 OD011070 |
Interdisciplinary Biomedical Research Training Program |
NORTH CAROLINA STATE UNIVERSITY |
Samuel L Jones |
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| Submission date |
Jul 19, 2022 |
| Last update date |
Aug 30, 2022 |
| Contact name |
Lauren V Schnabel |
| E-mail(s) |
lvschnab@ncsu.edu
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| Organization name |
North Carolina State University
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| Street address |
1060 William Moore Dr
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| City |
Raleigh |
| State/province |
North Carolina |
| ZIP/Postal code |
27606 |
| Country |
USA |
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| Platforms (1) |
| GPL21941 |
Illumina HiSeq 2500 (Equus caballus) |
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| Samples (18)
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| GSM6351489 |
Horse F, control |
| GSM6351490 |
Horse F, IL-1b licensed |
| GSM6351491 |
Horse F, IL-6 licensed |
| GSM6351492 |
Horse L, control |
| GSM6351493 |
Horse L, IL-1b licensed |
| GSM6351494 |
Horse L, IL-6 licensed |
| GSM6351495 |
Horse S, control |
| GSM6351496 |
Horse S, IL-1b licensed |
| GSM6351497 |
Horse S, IL-6 licensed |
| GSM6351498 |
Horse W, control |
| GSM6351499 |
Horse W, IL-1b licensed |
| GSM6351500 |
Horse W, IL-6 licensed |
| GSM6351501 |
Horse Y, control |
| GSM6351502 |
Horse Y, IL-1b licensed |
| GSM6351503 |
Horse Y, IL-6 licensed |
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| Relations |
| BioProject |
PRJNA860128 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208569_normalized_counts_A0vsA1.csv.gz |
251.6 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_A0vsA6.csv.gz |
258.2 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_F0vsF1.csv.gz |
255.7 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_F0vsF6.csv.gz |
259.4 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_L0vsL1.csv.gz |
258.3 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_L0vsL6.csv.gz |
260.6 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_S0vsS1.csv.gz |
259.4 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_S0vsS6.csv.gz |
260.9 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_W0vsW1.csv.gz |
253.6 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_W0vsW6.csv.gz |
260.1 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_Y0vsY1.csv.gz |
261.1 Kb |
(ftp)(http) |
CSV |
| GSE208569_normalized_counts_Y0vsY6.csv.gz |
262.7 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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