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| Status |
Public on Nov 20, 2023 |
| Title |
scRNA-seq analysis of CD11c+ cells from bronchoalveolar lavage fluid during the IAV (PR/8, H1N1) infection course |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
CX3CR1pos monocytes are mobilized upon infection and undergo monocyte-to-macrophage transition in inflamed tissues. Using scRNA-seq of CD11c+ cells from bronchoalveolar lavage fluid (BALF) infected with IAV (PR/8, H1N1 ,we demonstrate that, during severe viral pneumonia, bone marrow-derived macrophages (BMDM) pass co-ordinated trajectories of pro-inflammatory-to-tissue-healing phenotypes, before differentiating into tissue-resident alveolar macrophages, that retain a long-term tissue-protective phenotype.
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| Overall design |
scRNA-seq analysis of CD11c+ cells from bronchoalveolar lavage fluid during the IAV (PR/8, H1N1) infection course
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| Contributor(s) |
Herold S, Pervizaj-Oruqaj L, Glaser RD, Bartkuhn M |
| Citation(s) |
38167746 |
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| Submission date |
Jul 15, 2022 |
| Last update date |
Jan 08, 2024 |
| Contact name |
Rolf David Glaser |
| E-mail(s) |
rolf.d.glaser@bioinfsys.uni-giessen.de
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| Phone |
06419930574
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| Organization name |
Justus-Liebig-Universität Gießen
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| Department |
Biomedical Informatics and Systems Medicine
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| Street address |
Aulweg 128
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| City |
Giessen |
| ZIP/Postal code |
35392 |
| Country |
Germany |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (17)
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| GSM6340274 |
lung, 7 days after infection, replicate 1 |
| GSM6340275 |
lung, 7 days after infection, replicate 2 |
| GSM6340276 |
lung, 7 days after infection, replicate 3 |
| GSM6340277 |
lung, 14 days after infection, replicate 1 |
| GSM6340278 |
lung, 14 days after infection, replicate 2 |
| GSM6340279 |
lung, 14 days after infection, replicate 3 |
| GSM6340280 |
lung, 0 days after infection, replicate 1 |
| GSM6340281 |
lung, 0 days after infection, replicate 2 |
| GSM6340282 |
lung, 0 days after infection, replicate 3 |
| GSM6340283 |
lung, 0 days after infection, replicate 4 |
| GSM6340284 |
lung, 0 days after infection, replicate 5 |
| GSM6340285 |
lung, 35 days after infection, replicate 1 |
| GSM6340286 |
lung, 35 days after infection, replicate 2 |
| GSM6340287 |
lung, 35 days after infection, replicate 3 |
| GSM6340288 |
lung, 21 days after infection, replicate 1 |
| GSM6340289 |
lung, 21 days after infection, replicate 2 |
| GSM6340290 |
lung, 21 days after infection, replicate 3 |
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| Relations |
| BioProject |
PRJNA859143 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208294_Infection_timecourse_processed_data.h5ad.gz |
2.1 Gb |
(ftp)(http) |
H5AD |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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