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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 01, 2024 |
| Title |
Single-cell transcriptomic analysis reveals increased regeneration in diseased human inner ears |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Surgically procured utricles from organ donors and vestibular schwannoma patients underwent scRNAseq revealing unique transcriptional signatures among highly diverse sensory and non-sensory cells.
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| Overall design |
Utricles from vestibular schwannoma patients or organ donors were acquired and enzymatically digested followed by single cell dissociation. The cells then underwent single cell dissociation followed by 10x capture and sequencing.
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| Contributor(s) |
Taha JA, Alan CG |
| Citation(s) |
38844821 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| U24 DC020857 |
Human Ear Cellular Atlas |
STANFORD UNIVERSITY |
Alan Gi-Lun Cheng |
| K08 DC019683 |
Single cell analysis of mitotic regeneration in the mouse vestibular system |
VANDERBILT UNIVERSITY MEDICAL CENTER |
Taha A Jan |
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| Submission date |
Jul 09, 2022 |
| Last update date |
Jun 26, 2024 |
| Contact name |
Taha Jan |
| Organization name |
VUMC
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| Department |
Otolaryngology
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| Lab |
Taha Jan Lab
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| Street address |
2220 Pierce Ave, PRB 752
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| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37232 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (8)
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| GSM6319711 |
organ donor Right ear, replicate 1, scRNAseq |
| GSM6319712 |
organ donor Right ear, replicate 2, scRNAseq |
| GSM6319713 |
vestibular schwannoma left ear, replicate 1, scRNAseq |
| GSM6319714 |
vestibular schwannoma right ear, replicate 1, scRNAseq |
| GSM7795981 |
organ donor Left ear, replicate 1 |
| GSM7795982 |
organ donor Left ear, replicate 2 |
| GSM7795983 |
Vestibular schwannoma, vs3, replicate 1 |
| GSM7795984 |
Vestibular schwannoma, vs4, replicate 1 |
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| Relations |
| BioProject |
PRJNA857282 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE207817_RAW.tar |
193.5 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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