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| Status |
Public on Jun 05, 2023 |
| Title |
ORC1 binds to cis-transcribed RNAs for efficient activation of human origins [SNSseq_ASO] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
By investigating the RNA binding activity of human ORC1, we show that it interacts with RNAs transcribed at active origins, which is linked to ORC1 dynamic association to the chromatin and optimal origin firing in S phase.
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| Overall design |
Short Nascent Strand purification and sequencing from control or anti-GAA knocked down HCT116 cells, in duplicate
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| Contributor(s) |
Mas AM, Gómez M, Arcas A, Goñi E, Huarte M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 23, 2022 |
| Last update date |
Jun 07, 2023 |
| Contact name |
Maite Huarte |
| E-mail(s) |
maitehuarte@unav.es
|
| Organization name |
CIMA
|
| Street address |
c/ Avd Pio XII, 55
|
| City |
Pamplona |
| State/province |
Navarra |
| ZIP/Postal code |
31008 |
| Country |
Spain |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE173452 |
ORC1 binds to cis-transcribed RNAs for efficient activation of human origins |
|
| Relations |
| BioProject |
PRJNA852270 |
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