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| Status |
Public on Jun 23, 2023 |
| Title |
TET2 deficiency maintains leukemia stem cell self-renewal and subverts tumor immunity [model 1] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the function of TET2 in the development of acute myeloid leukemia (AML), we performed gene expression profiling analysis using data obtained from RNA-seq of AML cells carrying Tet2+/+ versus Tet2-/-.
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| Overall design |
We established NRAS/AE9a leukemic cells with bone marrow-derived hematopoietic stem cells from wildtype (WT) and Tet2-/- mice which was absent of exons 8 to 10. We then performed comparative gene expression profiling analysis of RNA-seq for these AML cells.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37541212/
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| |
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| Contributor(s) |
Chen J, Li Y, Su R, Dong L |
| Citation(s) |
37541212 |
| |
| Submission date |
Jun 20, 2022 |
| Last update date |
Aug 16, 2023 |
| Contact name |
Jianjun Chen |
| E-mail(s) |
jianchen@coh.org
|
| Phone |
6262185591
|
| Organization name |
Beckman Research Institute of City of Hope
|
| Department |
Systems Biology
|
| Lab |
Chen Lab
|
| Street address |
1218 S. 5th Ave., Room 2062
|
| City |
Monrovia |
| State/province |
CA |
| ZIP/Postal code |
91016 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA851020 |
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