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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 19, 2023 |
| Title |
Discovery and targeting of a noncanonical mechanism of sarcoma resistance to ADI-PEG20 mediated by the microenvironment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the effects of ADI-PEG20 and chloroquine treatment alone and in combination on the growth of Ass1 KO murine sarcomas, the BVMA01R murine sarcoma cell line was grafted into syngeneic C57BL/6J mice, and tumors were treated as indicated. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 tumors from each of the 4 treatment groups.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for BVMA01R tumors with and without both ADI-PEG20 and chloroquine treatment. 3 replicates of each.
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| Contributor(s) |
Rogers LC, Van Tine BA |
| Citation(s) |
37339179 |
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| Submission date |
Jun 17, 2022 |
| Last update date |
Sep 19, 2023 |
| Contact name |
Brian Van Tine |
| Organization name |
Washington University in St. Louis
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| Street address |
4515 McKinley Ave
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| City |
St. Louis |
| State/province |
Missouri |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| GSM6252837 |
BVMA01R tumor, CQ, rep1 |
| GSM6252838 |
BVMA01R tumor, CQ, rep2 |
| GSM6252839 |
BVMA01R tumor, CQ, rep3 |
| GSM6252840 |
BVMA01R tumor, ADI-PEG20, rep1 |
| GSM6252841 |
BVMA01R tumor, ADI-PEG20, rep2 |
| GSM6252842 |
BVMA01R tumor, ADI-PEG20, rep3 |
| GSM6252843 |
BVMA01R tumor, ADI-PEG20+CQ, rep1 |
| GSM6252844 |
BVMA01R tumor, ADI-PEG20+CQ, rep2 |
| GSM6252845 |
BVMA01R tumor, ADI-PEG20+CQ, rep3 |
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| Relations |
| BioProject |
PRJNA850408 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE206382_Merged_differential_expression_results.tsv.gz |
4.8 Mb |
(ftp)(http) |
TSV |
| GSE206382_group_ADI_PEG20-group_NT.KEGG_Signaling_and_Metabolism_singleDirection_results.tsv.gz |
51.3 Kb |
(ftp)(http) |
TSV |
| GSE206382_group_ADI_PEG20_CQ-group_NT.KEGG_Signaling_and_Metabolism_singleDirection_results.tsv.gz |
51.4 Kb |
(ftp)(http) |
TSV |
| GSE206382_group_CQ-group_NT.KEGG_Signaling_and_Metabolism_singleDirection_results.tsv.gz |
51.3 Kb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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