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| Status |
Public on Apr 23, 2023 |
| Title |
A cardiac developmental defect prevents thyroid hormone induced tachycardia in Resistance to Thyroid Hormone alpha |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Purpose: The objective of this study was to determine the cardiac gene expression prifile in the whole heart of mice with mutated thyroid receptor alpha 1 (TRα1R384C+/m) in control condition as well as after treatement with 3,3´,5-triiodo-L-thyronine (T3) for 12 days.
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| Overall design |
Methods: 3-6 month old wildtype (n=12) and TRα1R384C+/m (n=10) male mice were housed at 30°C with ad libitum access to drinking tap water containing T3 (0.5 mg/L) for 12 days. Control groups had ad libitum access to drinking tap water. All four groups had ad libitum access to chow food.
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| Contributor(s) |
Dore R, Sentis S, Geissler C, Johann K, Pedaran M, Ölkrug R, Lopez-Alcantara N, Sayk F, Iwen A, Dalley JW, Arner A, Mittag J, Watson L, Hollidge S, Krause C, Resch J, Franke A, Boysen T, Kirchner H, Chatterjee K, Lorenz K, Moran C, Rennie KL, Lyons G |
| Citation(s) |
37286550 |
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| Submission date |
Jun 17, 2022 |
| Last update date |
Aug 07, 2023 |
| Contact name |
Riccardo Dore |
| E-mail(s) |
riccardo.dore@uksh.de
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| Organization name |
University of Lübeck
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| Department |
Institute of Endocrinology and Diabetes
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| Lab |
Molecular Endocrinology
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| Street address |
Ratzeburger Allee 160
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| City |
Lübeck |
| State/province |
Schleswig-Holstein |
| ZIP/Postal code |
23562 |
| Country |
Germany |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA850193 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE206337_RAW.tar |
28.7 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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